Monoclonal antibody-based immunotherapies against cancer and other infectious diseases are highly advantageous comparing to conventional therapeutic approaches due to their high specificity and affinity towards well-defined targets. Antibody-drug conjugates (ADCs) inherit such superiorities and more remarkably, expand the therapeutic window of the conjugated drugs (payloads), which are usually highly toxic and diverse in their biochemical nature.
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Glycosylated proteins, including erythropoietin (EPO), monoclonal antibodies (MAb) and various hormones, constitute a large part of approved therapeutic biological drugs. Sialic acid is a negatively charged monosaccharide and exists as a terminal epitope on many glycans. The two most common sialic acids in biopharmaceuticals are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc).
The path of discovery of each therapeutic antibody is different. We focus on your antibody goals and work with you to achieve the ADCC/CDC enhancement goals. Whether you need expression optimization, recombinant protein production, antibody ADCC/CDC modification design, or cell line development, Creative Biolabs provides solutions to drive your research and accelerate your market.
The path of discovery of each therapeutic antibody is different. We focus on your antibody goals and work with you to achieve the ADCC/CDC enhancement goals. Whether you need expression optimization, recombinant protein production, antibody ADCC/CDC modification design, or cell line development, Creative Biolabs provides solutions to drive your research and accelerate your market.
The path of discovery of each therapeutic antibody is different. We focus on your antibody goals and work with you to achieve the ADCC/CDC enhancement goals. Whether you need expression optimization, recombinant protein production, antibody ADCC/CDC modification design, or cell line development, Creative Biolabs provides solutions to drive your research and accelerate your market.
Creative Biolabs has been dedicated to providing high-quality services in academic and life science worldwide. In the past decade, we have become a leader in discovering and manufacturing recombinant antibodies.
Creative Biolabs has been dedicated to providing high-quality services in academic and life science worldwide. In the past decade, we have become a leader in discovering and manufacturing recombinant antibodies.
Creative Biolabs has been dedicated to providing high-quality services in academic and life science worldwide. In the past decade, we have become a leader in discovering and manufacturing recombinant antibodies.
Creative Biolabs has been dedicated to providing high-quality services in academic and life science worldwide. In the past decade, we have become a leader in discovering and manufacturing recombinant antibodies.
Structures of alpha-galactosyl carbohydrates as complexes with lectins have revealed many of the attributes of protein-carbohydrate interactions such as the groove-type and end-on insertion mechanisms of binding. Creative Biolabs provides customized anti-glycan antibody services against different carbohydrate antigens by advanced technology platform to help your projects. Our professional scientists have extensive experience in antibody production, and bio-conjugation and are committed to providing high-quality services for our global clients.
As a leading company in the antibody development market, experts in Creative Biolabs possess enriched experience in bispecific antibody (BsAb) development. We can offer many different technical platforms and BsAb formats for customers and focus on ideal BsAbs design and development that meet all requirements of the customers.
Creative Biolabs possesses unchallenged experience in antibody engineering and recombinant protein generation. Multiple platforms of Creative Biolabs are elaborately integrated for providing customers one-stop services for bispecific antibody (BsAb) fragments development. Our cutting-edge techniques promise our BsAb products with not only high affinity and multiple valences to different targets, but also reliable safety for both academic and preclinical applications.
Chromatography is one of the most commonly used means to purify antibodies. The isolation and purification of BsAbs is the concentration of a specific antibody or antibodies and the removal of non-specific antibodies and contaminants. As a professional antibody manufacture supplier in the world, Creative Biolabs has established a series of affinity purification methods, including Protein A chromatography, to handle expectations for more mature antibody production. We’d like to help clients to obtain high-quality BsAbs with higher purity, lower costs, and less time through multiple effective p
To design drugs that have a broad therapeutic index by strongly targeting the disease while causing minimal injury to normal tissues still underpins the overarching goal of biopharmaceutical development. Antibody-drug conjugates (ADC) have been introduced into clinical practice in order to improve the efficacy of antibody-based targeted therapy. As a reliable antibody expert in the market, Creative Biolabs is focusing on cutting-edge bispecific antibody (BsAb) strategies that are currently under investigation and can provide a comprehensive portfolio of BsAb products to meet both the efficacy
Based on the outstanding expertise and extensive experience, Creative Biolabs has specially developed a systematic approach of multiplex cytokine and chemokine assays for research and clinical purposes. Our multiplex cytokine and chemokine assay services are designed to help you detect cytokines/chemokines of cells that can produce cytokine/chemokine, including immune cells, known as macrophages, B cells, and T cells, as well as endothelial cells, fibroblasts, and various stromal cells.
Regulatory T cells (Tregs) play a key role in inducing and maintaining immune tolerance, immunosuppression, and regulating abnormal immune responses. The importance of Treg in immune regulation and intermediary tolerance has been strongly demonstrated, and expanded polyclonal Treg is being developed for clinical applications. However, one problem is that the frequency of specific Tregs is very low. To overcome this issue, Creative Biolabs strive to "designate" Tregs by engineering Tregs to express receptors that recognize a given antigen. Therefore, we use retroviruses to transduce specific T
chemically programmed switch CAR
dog DLA typing
In the years spent in the development and production of CAR engineered γδ T cells, Creative Biolabs has acquired solid know-how in the field of the development of CAR-γδ T cells. The expertise offered to customers includes custom CAR generation for engineered γδ T cell, γδ T cell preparation, CAR transduction, and validation of CAR γδ T cells. Especially, we have accumulated rich experience in CAR transduction in γδ T cells. We can flexibly utilize a variety of transduction strategies for CAR transduction in γδ T cells.
Chemokines or chemoattractant cytokines are a family of small functional proteins inducing cell activation, migration, chemotaxis, and signaling via binding to corresponding chemokine receptors. Since the first discovery in 1977, more than 50 chemokines and 20 chemokine receptors have been identified over decades. The known chemokines are grouped into four subfamilies: CXC, CC, C, and CX3C, according to the number and position of four conserved cysteine residues at the N-terminus. The chemokine (C-C motif) ligand 2 (CCL2), also named monocyte chemoattractant protein 1 (MCP1), is the first ide